Journal of Medicine & Health <p>Journal of Medicine and Health (JMH) is an open access journal (OAJ), a periodic scientific publication biannually online published on February and August; using review and screening system by peer group reviewer. JMH receives original research articles which related to medicine, health, new developing therapy from traditional medicine or herbs &nbsp;and developing clinical therapy. JMH also receives otiginal review articles, case report, continuing medicine and health study. Articles should be written in good English or Indonesian language.</p> <p>e-ISSN:&nbsp;<strong>2442-5257</strong></p> Universitas Kristen Maranatha en-US Journal of Medicine & Health 2442-5257 The Detection of Pathogenic Fungi on Prayer Rugs of The Mosques at Jatinangor Campus of Universitas Padjadjaran <p>Fungus easily grows in the plateau area with warm moist air. The fungus can enter and contaminate mosque rooms, especially on the surface of prayer rugs. If pathogenic fungi grow on prayer rugs, they can increase the health risk of those who come into contact with them. This research aimed to detect and identify pathogenic fungi on prayer rugs of the mosques in Jatinangor campus of Universitas Padjadjaran using laboratoric descriptive method. The data was collected by sampling of dust from the surface of prayer rugs, fungal culturing and mold identification. The existence of pathogenic fungi has been investigated and observed in twenty-eight samples of thirty mosques using simple random sampling. Sabouraud Dextrose Agar was the chosen medium to grow pathogenic fungi. We found fungal growth in all samples with a total of 8 fungal species (Alternaria spp, Aspergillus spp, Candida spp, Fonsecaea spp, Mucor spp, Penicillium spp, Rhizopus spp, Rhodotorula spp) which are opportunistic fungi; however, no pathogenic fungi were found.<br>Keywords : pathogenic fungi, prayer rugs, fungus, Aspergillus spp., Candida spp.</p> Faturrachman Faturrachman Yanti Mulyana ##submission.copyrightStatement## 2019-02-27 2019-02-27 2 3 10.28932/jmh.v2i3.1220 Clinical Profile of TB in Children at Pediatric Outpatient Clinic Hasan Sadikin Hospital Bandung 2016 <p><em>The diagnosis process of TB in children is complicated. Bacteriological exam is needed to establish diagnosis,</em> <em>but it is not possible to be done</em><em> in </em><em>children. Clinical symptoms are the main criteria for TB diagnosis in children. </em><em>This study aimed to provide clinical profile of TB in children and was conducted using descriptive design. The data was taken from medical record of children with TB at </em><em>RSHS pediatric outpatient clinic </em><em>from</em><em> January 2016 </em><em>to </em><em>December 2016. We collected 104 subjects using simple random sampling method. </em><em>We found </em><em>out </em><em>that 64 subjects (61.54%) was diagnosed as lung TB and 40 (38.46%) with extra</em><em>-</em><em>pulmonary TB. Contact with the source of transmission was found </em><em>in</em><em> 33 patients (60%). We found </em><em>that </em><em>clinical symptoms of the subjects were fever</em> <em>&nbsp;2 weeks (62.5%), weight increase difficulty (49%), lymphnode enlargement (36.5%), </em><em>cough &gt;=</em><em>&nbsp;2 weeks (14.4%), chest tightness (7.7%), bone swelling (4%), and night sweats (2%). We concluded that </em><em>clinical symptoms that are found mostly </em><em>in</em><em> children with TB are fever</em> <em>&nbsp;&gt;= 2 weeks, weight increase difficulty, lymphnode enlargement, </em><em>cough &gt;=</em><em>&nbsp;2 week, chest tightness, bony swelling, and night sweats</em><em>.</em></p> <p><em>&nbsp;</em></p> <p><strong><em>&nbsp;</em></strong></p> <p><strong><em>Keywords: </em></strong><em>clinical profile, </em><em>t</em><em>uberculosis</em><em>, TB infection in children</em></p> Fadiya N Soekotjo Sri Sudarwati Anggraini Alam ##submission.copyrightStatement## 2019-02-27 2019-02-27 2 3 10.28932/jmh.v2i3.1221 The Influence of Obesity on Blood Pressure in Early Adulthood and Middle Adulthood Males <p><em>Hypertension is commonly found in obesity patients. Age </em><em>a</em><em>ffect</em><em>s</em><em> the occurrence of hypertension. The aim of this study is to determine the effect of obesity on blood pressure levels in early adulthood males (&lt;35 years) and middle adulthood males (?35 years). This is an observational analytic study using data from medical check-up records of </em><em>male</em><em> adult office workers in Bandung. The data was analyzed with Mann-Whitney test (? = 0</em><em>.</em><em>05) and Chi-Square to find the odds ratio (OR). The results showed that out of 110 data in medical records, there were 79 (71.82%) obese and 31 (28.18%) non-obese. In early adulthood males (&lt;35 years) there is no significant difference between non-obese with obese in systolic blood pressure (p=0.779) and diastolic blood pressure (p=0.779). In middle adulthood males (?35 years) there was a highly significant difference between non-obese with obese on systolic blood pressure (p=0.001) and diastolic blood pressure (p=0.003). There was a significant relationship between obesity and hypertension (p=0.048) with OR=3.73. In conclusion, in early adulthood males (&lt;35 years) obese does not have an effect on the development of hypertension, while in middle adulthood males, obesity increase</em><em>s</em><em> the risk of developing hypertension </em><em>by </em><em>3.73 times.</em></p> <p><em>&nbsp;</em></p> <p><em>&nbsp;</em></p> <p><strong><em>Keywords:</em></strong><em> obesity, blood pressure, early adulthood males, middle adulthood males</em></p> Muhammad O A Eusman Hana Ratnawati Mariska Elisabeth ##submission.copyrightStatement## 2019-02-27 2019-02-27 2 3 10.28932/jmh.v2i3.1222 Factors Affecting Caesarean Labor in RSUD Lembang in 2017 <p><em>Indonesian Maternal Mortality Ratio (MMR) based on </em><em>the </em><em>Survei Demografi Kesehatan Indonesia (SDKI) </em><em>in</em><em> 2012 is 356/100.000 live birth whereas the target of Sustainable Development Goals (SDG’s 70/100</em><em>,</em><em>000 live birth by 2030. A decent labor assistance in both vaginal and sectio caesarean labor is necessary in reducing MMR. This study aimed to analyze the relation</em><em>ship</em><em> between maternal age, parity and payment method with labor through caesarean section. This is an observational analytic study using cross sectional design. </em><em>The d</em><em>ata was obtained&nbsp; through secondary data from medical record. During 2017 there were 183 caesarean section</em><em>s</em><em> in RSUD Lembang as our research location. </em><em>The d</em><em>ata was analyzed univariately and bivariately </em><em>by </em><em>using Chi Square test (?=0.05). The results shows that factors associated with caesarean labor are maternal age (p=0.032; OR=4.617), parity (p=0.035; OR=4.442) and payment method (p=0.036; OR=4.417). It can be concluded that maternal age, parity and payment method affect caesarean labor.</em></p> <p><em>&nbsp;</em></p> <p><strong><em>Keywords: </em></strong><em>caesarean labor, caesarean section, age, parity, payment method</em></p> Regina A B Pratiwi Rimonta F Gunanegara July Ivone ##submission.copyrightStatement## 2019-02-28 2019-02-28 2 3 10.28932/jmh.v2i3.1223 Clinical Manifestation of Peripheral Artery Disease in Type 2 Diabetes Melitus with Ankle Branchial Index Measurement <p><em>Diabetes mellitus (DM) is a metabolic disease that has a high prevalence in Asia, including Indonesia. One of the complications of DM is Peripheral Artery Disease (PAP). Ankle Brachial Index (ABI) measurement is a simple and non-invasive methods that can be used for PAP evaluation. This study aims to provide an overview of the clinical manifestations of PAP and the value of ABI as early detection of PAP in patients with type-2 DM. This research uses quantitative descriptive design studies. The research variables used to assess PAP were ABI values, age, sex, duration of diabetes mellitus, hypertension, and clinical manifestations of PAP such as pain, intermittent claudication, muscle atrophy, skin discoloration, sweating, wound healing impairment, and gangrene. This study involved 92 research subjects. From the study we found out that the normal ABI value and the ABI value of the PAP category in patients with type 2 diabetes were 91.3% and 7.6%. The ABI value of the PAP category in DM patients is more commonly found in women (6.5%), adult patients (5.4%), duration of DM up to 2 years (5.4%), and with hypertension (5.4%) . Pain and numbness are the most common clinical manifestations of PAP in DM patients.</em></p> <p><em>&nbsp;</em></p> <p><em>&nbsp;</em></p> <p><strong><em>Keywords:</em></strong><em> diabetes mellitus, ankle brachial index, peripheral artery disease.</em></p> Winny W Nasution Henhen Heryaman Januar W Martha Apen A Ridwan ##submission.copyrightStatement## 2019-02-28 2019-02-28 2 3 10.28932/jmh.v2i3.1224 Clinical Profile of Stroke Patients with Vertigo in Hasan Sadikin General Hospital Bandung Neurology Ward <p><em>&nbsp;Vertigo often occurs </em><em>from </em><em>the age</em><em>s</em><em> of 18 </em><em>to </em><em>79 years with a prevalence of 7.4%. Central vertigo is less common than peripheral vertigo, but </em><em>it </em><em>can worsen disability in stroke patients. This study aims to determine the profile of stroke patients with vertigo in Hasan Sadikin General Hospital Bandung Neurology Ward. This is a retrospective descriptive study, using medical record data from 2013 </em><em>to </em><em>2017, and collected 173 medical record data. The results showed that most stroke patients with vertigo were women (59%), the most age group was 55-64 years (34.1%), the most common type of stroke was ischemic stroke (75.7%), the most disturbance regarding the vertebrobasilar system </em><em>was </em><em>(72.8%), </em><em>the </em><em>most patients </em><em>got</em><em> the first stroke </em><em>was </em><em>(52.6%), 60.7% of patients suffered from hypertension, 23.1% of patients suffered from hyperlipidemia 40 (23.1%), and 22% of patients suffered from diabetes mellitus type 2. This study concludes that stroke patients who experience vertigo are more common in women,</em> <em>and in the 55-64 year age group. The most common stroke is ischemic in the vertebrobasilar system. Most symptoms in stroke patients with vertigo are dizziness not affected by position, vomiting and nystagmus. Hypertension, hyperlipidemia and diabetes mellitus play an important role in the incidence of stroke in patients.</em></p> <p><strong><em>&nbsp;</em></strong></p> <p><strong><em>Keywords</em></strong><em>: vertigo, risk factor, stroke, vertebrobasilar</em></p> Amany Khansa Aih Cahyani Lisda Amalia ##submission.copyrightStatement## 2019-02-28 2019-02-28 2 3 10.28932/jmh.v2i3.1225 Outcome Predictors in Patient with Traumatic Intracerebral Hemorrhage in Hasan Sadikin General Hospital Bandung <p><em>Predictions about patient outcomes can help doctors make decisions. Intracerebral hemorrhage </em><em>acccompanied by</em><em> brain injury can increase mortality but specific studies on outcomes of patients with traumatic intracerebral hemorrhage are still rare. The purpose of this study was to determine the factors that influence the outcome of traumatic intracerebral hemorrhage patients in the RSHS period from January to December 2017. This is an observational study with cross sectional method, categorical comparative analytic. The study involved 60 traumatic intracerebral hemorrhages aged ? 15 years who were hospitalized </em><em>in</em><em> RSHS. </em><em>The d</em><em>ata was analyzed univariately and bivariately using Chi Square statistical test, Eta correlation test and contingency coefficient. The results showed age (p = 0.003), GCS scores assessed at admission (p &lt;0.001), and the presence or absence of other brain</em> <em>hemorrhages (p = 0.050) significantly affected the patient's outcome. Gender (p = 0.932), mechanism of injury (p = 0.739), and pupillary response (p = 0.056) did not affect </em><em>the </em><em>outcome significantly. In conclusion, the factors that influence the outcome of traumatic intracerebral hemorrhage patients are age, GCS score, and presence or absence of other brain hemorrhages.</em></p> <p><strong><em>&nbsp;</em></strong></p> <p><strong><em>Keywords</em></strong><em>: intracerebral hemorrhage, trauma, predictors, outcome</em></p> Tara M Mulyawan M Zafrullah Arifin Firman P Tjahjono ##submission.copyrightStatement## 2019-02-28 2019-02-28 2 3 10.28932/jmh.v2i3.1231 Milk Consumption Correlates with Body Height in Children <p>Growth in children is very important because it affects a person's height as an adult.<br>Qualified and adequate nutrition play a significant role in growth. Adequate milk consumption<br>can affect bone growth which ultimately affects height and helps reduce the risk of bone loss.<br>The purpose of this study was to determine the correlation between milk consumption and<br>height in children. This study is an analytic observational study, involving 126 subjects aged 6-<br>9 years from an elementary school in Bandung. The sample was taken by whole sampling<br>technique. Data collection was carried out using questionnaires and height measurements. The<br>data was analyzed using the Gamma correlation test. The statistical results showed a significant<br>relationship between the frequency of milk consumption and height (p = 0.044) with a medium<br>correlation coefficient (r = 0.430) and a positive correlation direction which meant an increase<br>in the frequency of milk consumption along with the increasing height in children aged 6-9<br>years. We concluded that milk consumption correlates with body height in children.<br>Keywords: milk consumption, body height, children, correlation</p> Evan Tirtasaputra Grace Puspasari Teresa Lucretia ##submission.copyrightStatement## 2019-02-28 2019-02-28 2 3 10.28932/jmh.v2i3.1232 Association between Fever during Admission and Outcome of Treatment in Tuberculous Meningitis Patients in Hasan Sadikin General Hospital Bandung <p>Tuberculous meningitis (TBM) is the most common type of meningitis with a high<br>mortality rate (20-41%). There are limited data on factors associated with outcome of<br>treatment, especially in Indonesia. Fever is a common inflammatory process in meningitis<br>patients. This study aims to investigate the association between fever during admission and<br>outcome of treatment in TBM patients treated in the In-patient Neurology Department at Hasan<br>Sadikin Hospital Bandung. This is an observational retrospective cohort study conducted by<br>using medical records from 2017. The inclusion criteria of this study were all medical records<br>of inpatients who were diagnosed as TBM and ?18 years old, while the exclusion criteria were<br>incomplete medical records. The variables in this study were age, gender, body temperature,<br>classification of TBM, and Glasglow Outcome Scale (GOS). There were 125 medical records<br>which fulfilled the inclusion criteria. Kruskal- Wallis test showed that fever was not<br>significantly associated with GOS (p=0.193). In conclusion, fever during admission was not<br>associated with GOS in TBM patients.<br>Keywords: tuberculous meningitis, fever, Glasglow Outcome Scale, outcome</p> Regita A Kuswanto Ahmad Rizal R Raspati C Koesoemadinata ##submission.copyrightStatement## 2019-02-28 2019-02-28 2 3 10.28932/jmh.v2i3.1233 Hypolipidemic Effects of Pea Protein Hydrolysates on Lipid Profile and Uric Acid in Cisplatin-Induced Nephropathy Rats <p>The usage of Cisplatin (CP) can cause side effects such as toxicity and impaired kidney<br>function. Poor kidney function causes dyslipidemia and hyperuricemia. Researchers in Canada<br>state that pea protein hydrolysates can improve kidney function. The aim was to examine the<br>hypolipidemic effect of 8 types of pea protein hydrolysate on lipid profiles and uric acid in CPinduced rats in purpose to find protein sources origin of Indonesia for kidney therapy. This is a<br>true experimental study using fifty female Wistar rats divided into 10 treatment groups.We<br>administered 8 types of pea protein hydrolysate for 30 days. On day 7 all rats (except negative<br>control) were induced CP intraperitoneally. Study parameters was evaluated on days 12 and<br>30. In general, all treatments showed good hypolipidemic effects, and differed significantly from<br>CP group (p &lt;0.01). The group that showed lowest total cholesterol, LDL and triglyceride<br>results is yellow pea protein hydrolysate Neutrase; HDL: green peas protein hydrolysate<br>bromelain, uric acid: protein hydrolysate of pea protein isolate bromelain. As conclusion,<br>protein hydrolysates of pea has good hypolipidemic effects on Lipid profile and Uric Acid in<br>CP-induced nephropathy Rats.</p> <p><br>Keywords: protein hydrolysates, green peas, neutrase, bromelain, lipid profiles</p> Meilinah Hidayat Sijani Prahastuti Andreas A Soemardji Khomaini Hasan Gabriella Audrey Janifer Gabriella Petrisia Luvina Cicilia Liempapas et al ##submission.copyrightStatement## 2019-02-28 2019-02-28 2 3 10.28932/jmh.v2i3.1234 Potential of Fucoidan From Brown Seaweeds (Sargassum sp.) as Innovation Therapy on Breast Cancer <p><em>Breast cancer is a non-communicable disease and a major health problem in the world. Based on </em><em>the </em><em>data from WHO in 2012, the incidence of breast cancer is reported as 1.67 million cases. One cause of the highest morbidity and mortality in breast cancer is chemoresistance. Various attempts were made to solve this </em><em>problem</em><em>. The purpose of this review is to describe the potential of fucoidan from brown seaweeds (Sargassum sp.) as innovation therapy on breast cancer. Fucoidan as proapoptotic agents affect many target cells (multi-targets) to induce apoptosis. Fucoidan has a potential for a new treatment of breast cancer because of its potent proapoptotic and anti-metastatic properties. However, no research </em><em>has yet </em><em>evaluate</em><em>d</em><em> this in clinical trial. </em><em>Hence, </em><em>&nbsp;further studies are needed to confirm the true potential of fucoidan from brown seaweeds as therapy for breast cancer.</em></p> <p><strong><em>&nbsp;</em></strong></p> <p><strong><em>&nbsp;</em></strong></p> <p><strong><em>Keywords</em></strong><em>: anti-proliferative agents, pro-apoptotic agents, fucoidan, breast cancer</em></p> Agung B S Satyarsa ##submission.copyrightStatement## 2019-02-28 2019-02-28 2 3 10.28932/jmh.v2i3.1235 PEER REVIEW <p>We would like to thank our peer reviewers for the precious contributions in providing clinical, scientific, and methodological expertise for JMH Volume 2 Number 3 February 2019. We appreciate every thoughtful review of submitted manuscripts and for making important contributions to improve the scientific quality of articles published in JMH. We listed the names in alphabetical order.</p> <p><br>Abram Pratama,dr.,SpPD<br>DR.rer.nat. Afiat Berbudi, dr., M.Kes<br>DR.Med. Muhammad Hasan Bashari, dr., M.Kes.<br>Cindra Paskaria,dr.,MKM<br>Decky Gunawan,dr., M.Kes,AIFO<br>Demes Chornelia Martantiningtyas, S.Si., M.Sc<br>Dono Pranoto,dr.,SpB., M.Kes<br>Drs. Eko Suhartono, M.Sc<br>Fanny Rahardja,dr.,M.Si<br>Grace Puspasari,dr.,M.Gizi<br>DR.Guswan Wiwaha, dr., MM<br>Dr. dr. Hana Ratnawati ,M.Kes., PA(K)<br>Hanna, dr., M.Kes., PhD., AIFO<br>Julia Windi Gunadi,dr.,M.Kes<br>Larissa, dr., Sp.PK, MMRS<br>Limdawati Kwee,dr.,SpPD., FPCP<br>Lusiana Darsono,dr., M.Kes.<br>Prof.Dr. Ridad Agoes,MPH<br>DR. Sadeli Masria, dr., DMM., MS., Sp.MK.<br>Stella Tinia Hasianna,dr., M.Kes.,IBCLC<br>DR. Teresa Liliana W, S.Si., M.Kes., PA(K)<br>DR.Titik Respati,drg., MScPH<br>Yenni Limyati,dr.,Sp.KFR<br>DR.Yudi Mulyana H.,dr.,SpOG(K)<br>Yuktiana Kharisma, dr., M.Kes</p> Editorial Team ##submission.copyrightStatement## 2019-03-06 2019-03-06 2 3 10.28932/jmh.v2i3.1241