The Effect of Bee Pollen on SGOT, SGPT Levels and Liver Histopathological Images of Male Rats Wistar Induced by High Fat Diet

  • Sijani Prahastuti Faculty of Medicine Maranatha Christian University
  • Jeanny E Ladi
  • Kartika Dewi
  • Felicia Albertina
  • Muhammad K Imam

Abstract

Dyslipidemia is a risk factor for Non Alcoholic Fatty Liver Disease causing hepatocyte damage.     Bee pollen has hypolipodemic, anti-inflammatory effects. The purpose of the study was to analyze the effects of Bee Pollen on the levels of SGOT, SGPT, and its effects on the liver’s histopathologic. The experimental laboratory research method, 30 rats divided into 6 groups (n = 5). HFD  was given for 28 days, Simvastatin and Bee Pollen were given from 15 until 28 days.  SGOT, SGPT were examined  at 0, 15, 29 days by spectrophotometry (340 nm). Histopathological liver examination at 29 days. Results: The levels of SGOT, SGPT between Bee pollen 1 (18 mg/kgBW/day),  2 (36 mg /kgBW/day),  3 (72 mg /kgBW/day) with HFD were very significant differences. The levels of SGOT Bee Pollen 1,2,3 compared to simvastatin were not significantly different. SGPT Bee Pollen 3 levels compared to simvastatin there were no significant differences. Measurement of the degree of cloudy swollen cells, portal inflammation, bridging fibrosis, periportal fibrosis between Bee Pollen 1, 2 with HFD there is a significant difference, Bee Pollen 3 and HFD differ very significantly. Conclusion: Bee Pollen can reduce levels of SGOT, SGPT, its potential effects is equivalent to simvastatin on reducing levels of SGOT, SGPT and improved the histopathological image of the liver on male rats wistar induced by high-fat diet. .   Keywords : Dyslipidemia, SGOT, SGPT, Bee pollen, Histopatological Image  

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Author Biography

Sijani Prahastuti, Faculty of Medicine Maranatha Christian University
Nama Lengkap                         :  Sijani Prahastuti, dr. M.Kes.Asal Institusi                            :  Fakultas Kedokteran Universitas Kristen MaranathaBidang Ilmu                             :  BiokimiaPendidikan Terakhir                  : S2Jumlah publikasi nasional 3 (tiga) tahun terakhir:a. Penulis Utama                     :    Prahastuti S., Hidayat M, Kurniadi MW. Christiany S. Potency of Black Soybean (Glycine max L. Merr) and Jati Belanda Leaves (Guazuma ulmifolia Lamk) for Dyslipidemia Treatment in Vitro . Journal of Medicine and Health. 2016;1(3):200-13.Potency of Black Soybean (Glycine max L. Merr) and Jati Belanda Leaves (Guazuma ulmifolia Lamk) for Dyslipidemia Treatment in Vitro . Journal of Medicine and Health. ISSN 2442-5257. 2016;1(3):200-13.                                b. Anggota Penulis :-  Hidayat M, Soeng S, Prahastuti S. Pengujian Aktivitas Lipase Inhibitor Ekstrak Etanol dan  Hasil Fraksionasi dari Kedelai Detam 1 dan Daun Jati Belanda. Jurnal Chimica et Natura Acta. 2014. 2(1): 76-82.-  Hidayat M, Soeng S, Prahastuti S, Hermanto PT, Andhika YK. Aktivitas Antioksidan dan Antitrigliserida Ekstrak Tunggal Kedelai, Daun Jati Belanda serta Kombinasinya. Bionatura - Jurnal Ilmu Hayati dan Fisik. ISSN 1411-0903.  2014.16: 2. p 89-94.- Hidayat M, Soeng S, Prahastuti S, Kwan Marlisa, Yonathan Ari K, Nikita Renadia. Combination Effects of Ethanol Extract Detam 1 Soybean and Jati Belanda Leaves to Body Weight, Cholesterol and Triglyceride in Male Wistar Rats. Journal of The Indonesian Medical Association. Majalah Kedokteran Indonesia IDI. 2014;64(8):372-376. http;//indonesia.digitaljournals.org.index.php/idnmed/issue/archive.  - Hidayat M, Prahastuti S, Dewi E, Safitri D, Soemardji AA. Uji Toksisitas Subkronis dari Kombinasi Ekstrak Etanol Kedelai Detam 1 dan Jati Belanda terhadap Fungsi, Berat dan Histopatologi Ginjal Tikus Wistar. JMH. Journal of Medicine and Health. 2016;1(4):326-40.- Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney . Journal of Medicine and Health. ISSN 2442-5257.  2016;1(4):326-40. 6. Jumlah publikasi internasional 3 (tiga) tahun terakhir:1. Penulis Utama                     : ………………………..    Judul                                   : ……………………….2. Anggota Penulis :-  Hidayat M, Soeng S, Prahastuti S, Tiono H, Krisetya YA, Sugiono M. Characteristics of  Ethanol Extract of Detam 1 Indonesian Soybean, Jati Belanda Leaves and the Effets of their Combinations to Weight Gain  and the Jejunum Histopathological Changes in  Male Wistar Rats. European Journal Of Medicinal Plants. European Journal of Medicinal Plants. EJMP.2015: 7 (2): 87-98.ISSN: 2231-0894.- Hidayat M, Soeng S, Prahastuti S, Erawijantari PP and Widowati W. Inhibitory Potential of Ethanol Extract of Detam 1 Soybean (Glycine max) seed and Jati Belanda (Guazuma ulmifolia) leaves on Adipogenesis and Obesity Models in 3T3-L1 Cell Line. Journal of Scientific Research & Reports. JSRR. 2015:6(4): 304-312. ISSN: 2320-0227.- Hidayat M, Prahastuti S, Dewi E, Safitri D, Soemardji AA. Subchronic Toxicity Test of Combination Ethanol Extract of Detam 1 Soybean (Glycine max L.Merr) and Jati Belanda leaves (Guazuma ulmifolia LamK) toward Function, Weight and Histopathological Wistar Rats Liver. AJPCR. Asian Journal of Pharmaceutical and Clinical Research. 2016;9(6)- Characteristics of  Ethanol Extract of Detam 1 Indonesian Soybean, Jati Belanda Leaves and the Effets of their Combinations to Weight Gain  and the Jejunum Histopathological Changes in  Male Wistar Rats. European Journal Of Medicinal Plants. European Journal of Medicinal Plants. EJMP.2015: 7 (2): 87-98.ISSN: 2231-0894.
Published
2020-02-27
How to Cite
1.
Prahastuti S, Ladi J, Dewi K, Albertina F, Imam M. The Effect of Bee Pollen on SGOT, SGPT Levels and Liver Histopathological Images of Male Rats Wistar Induced by High Fat Diet. JMH [Internet]. 27Feb.2020 [cited 7Aug.2020];2(5). Available from: https://journal.maranatha.edu/index.php/jmh/article/view/2040
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Articles